CROSH student member Sharmin Atker is defending her Critical Review Essay on “Examining The Role of Carotenoids and Retinoids in Modulating Cellular Response to Oxidative stress: An Evidence-Based Approach”

All are welcome to attend by Webex. Email croshtech@laurentian.ca for the link.

Supervisor: Dr. Alex R. Moise

Abstract: Oxidative stress, resulting from an imbalance between reactive oxygen species (ROS) production and

antioxidant defense systems, plays a critical role in cellular damage and the progression of diseases such as

neurodegeneration, cardiovascular disorders and cancer. Carotenoids and retinoids, naturally occurring compounds with

potent antioxidant properties, counteract oxidative stress by scavenging free radicals, preventing lipid peroxidation and

regulating gene expression. This review explores the bioavailability, metabolism and molecular mechanisms of

carotenoids, including β-carotene, lutein, and lycopene. Additionally, it investigates the influence of retinoic acid on

gene regulation through retinoic acid receptors (RARs) and retinoid X receptors (RXRs), emphasizing their impact on

cellular differentiation, apoptosis and oxidative defense. The therapeutic potential of carotenoids in neurodegenerative

disorders, cardiovascular health and cancer treatment is discussed. The review concludes that while carotenoids and

retinoids offer significant protection against oxidative stress, their clinical application requires careful consideration of

bioavailability, dosage and individual genetic variations to maximize therapeutic outcomes.