Monkeypox is a zoonotic disease caused by the monkeypox virus (MPXV), which produces lesions similar to smallpox among human beings. The MPXV outbreak (which is endemic to rainforest African countries) has emerged as a major global concern. In recent years, exposure to MPXV was reported among certain occupational groups, including veterinary staff, pet store employees, animal distributors, and healthcare workers (HCWs), particularly those who work in frontline positions. Hospitals provide a conducive environment for transmitting infectious diseases(e.g., COVID-19 transmission). This warrants the need to develop an effective infection control management plan. Therefore, the authors of this commentary sought to describe a framework for workplace risk assessment and prevention strategies for controlling infection transmission in occupational settings (e.g. hospitals). Occupational health programs, vaccination campaigns at work sites, and educational initiatives to increase knowledge and awareness about effective infection control measures among medical staff and the general public will be essential to prevent future outbreaks. A comprehensive strategy based on an enhanced and multidisciplinary activity coordinated by occupational health services and close collaboration between occupational and public health stakeholders will be warranted. National outbreak preparedness and global coordination efforts for improving the syndemic surveillance of the current global outbreaks in developing and developed countries, per the “One Health” approach, may tackle even the current MPXV outbreak and prevent the spread of the virus among HCWs and the communit